Bacterial defence molecules target viral DNA
نویسندگان
چکیده
منابع مشابه
PKR evolution in viral defence
The innate immune system provides the first line of host defense to pathogens. Part of this response is mediated by the cellular RNA-activated protein kinase, PKR. In a recent article published in the journal Nature [1], findings on the rate of evolution of PKR and how it relates to K3L, a pseudosubstrate viral mimic from poxviruses, are presented. The authors employ an impressive diversity of ...
متن کاملDefence against bacterial drug resistance.
How does resistance arise in bacteria ? One process is simply selection; treatment with an antibiotic eliminates sensitive strains and enables an originally very small minority of resistant ones to survive and spread. This is undoubtedly what happened among staphylococci in the early days of penicillin. When exposure to a drug-antibiotic or synthetic-is followed by resistance in a previously se...
متن کاملMajor bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems
Current understanding of microorganism-virus interactions, which shape the evolution and functioning of Earth's ecosystems, is based primarily on cultivated organisms. Here we investigate thousands of viral and microbial genomes recovered using a cultivation-independent approach to study the frequency, variety and taxonomic distribution of viral defence mechanisms. CRISPR-Cas systems that confe...
متن کاملHelminth defence molecules—immunomodulators designed by parasites!
HELMINTH DEFENCE MOLECULES (HDMs)—ANTIMICROBIALS OR IMMUNOMODULATORS? Parasitic helminths (worms) are one of the most successful animal groups in nature. They are large multicellular organisms and therefore cannot penetrate host cells but must reside inside tissue or organs. They infect over 1 billion people globally, mostly in tropical/sub-tropical regions, taking an enormous toll on animal an...
متن کاملGene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA
PURPOSE The pathogenesis of age-related macular degeneration (AMD) is associated with systemic and local inflammation. Various studies suggested that viral or bacterial infection may aggravate retinal inflammation in the aged retina. We compared the effects of synthetic viral RNA (poly(I:C)) and viral/bacterial DNA (CpG-ODN) on the expression of genes known to be involved in the development of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/d41586-018-07576-7